Phase II and Phase III attrition rates 2011–2012

Laparoscopic Radiofrequency Fibroid Ablation: Phase II and Phase III Results

BACKGROUND AND OBJECTIVES To review phase II and phase III treatments of symptomatic uterine fibroids (myomas) using laparoscopic radiofrequency volumetric thermal ablation (RFVTA). METHODS We performed a retrospective, multicenter clinical analysis of 206 consecutive cases of ultrasound-guided laparoscopic RFVTA of symptomatic myomas conducted on an outpatient basis under two phase II studie...

Phase II logistic profile monitoring

In many industrial and non-industrial applications the quality of a process or product is characterized by a relationship between a response variable and one or more explanatory variables. This relationship is referred to as profile. In the past decade, profile monitoring has been extensively studied under the normal response variable, but it has paid a little attention to the profile with the ...

Chemical Modification of Activated Carbon and Its Application for Solid Phase Extraction of Copper(II) and Iron(III) Ions

Powder activated carbon surface (AC) was grinded and modified and altered procedure thorough a facile and easy chemical reaction to appearance of 2-((3silylpropylimino)1-methyl) phenol (AC- (SPIMP)). Subsequently, this novel sorbent efficiently applied for the extraction and preconcentration of some metal ions from real samples. Preliminary the influences of variables such as pH, amounts of rea...

Lipid profile and effect of statin treatment in pooled phase II and phase III baricitinib studies.

OBJECTIVES Lipid profiles are altered by active disease in patients with rheumatoid arthritis (RA) and may be further modified by treatment with Janus kinase inhibitors and other disease-modifying antirheumatic drugs. METHODS Lipid data were analysed from phase II and III studies of 4 mg (n=997) and 2 mg (n=479) oral baricitinib administered once daily in patients with moderate-to-severe acti...

Novel methodologic approaches to phase I, II, and III trials.